Objective Whether HMG-CoA-reductase inhibition, the main mechanism of statins, plays a
role in the pathogenesis of osteoporosis, is not entirely known so far. Consequently, this …

Introduction Both diabetes mellitus and being female significantly increase the risk of being
diagnosed with major depressive disorder (MDD). The diagnosis of MDD, combined with …

Background Multimorbidity, the co-occurrence of two or more diseases in one patient, is a
frequent phenomenon. Understanding how different diseases condition each other over the …

Background Systemic inflammation measured by the neutrophil-to-lymphocyte ratio (NLR),
leucocyte-to-lymphocyte ratio (LLR), platelet-to-lymphocyte ratio (PLR), monocyte-to …

Background Evidence differentiating the effect of biological sex from psychosociocultural
factors (gender) in different societies and its relation to cardiovascular diseases is scarce …

Introduction Gremlin-1 is a peptide that functions as an antagonist to bone morphogenic
proteins and is overexpressed in obesity and type 2 diabetes mellitus. Gremlin-1 has not yet …

Aims The risk for developing venous thromboembolism (VTE) is about equal in both sexes.
Research suggests diabetes mellitus (DM) is a risk factor for pulmonary embolism and deep …

Background: In general, the risk to develop Parkinson's disease (PD) is higher in men
compared to women. Besides male sex and genetics, research suggests diabetes mellitus …

Recent studies have shown higher levels of CTRP-1 (C1QTNF-related protein) in patients
with type 2 diabetes compared to controls. We aimed at investigating CTRP-1 in gestational …

Abstract Glypican-4 (GPC-4) is an adipokine that enhances insulin receptor signaling.
Plasma concentrations were found to be elevated in patients with prediabetes but reduced …