[HTML][HTML] Fibroblasts in fibrosis: novel roles and mediators
RT Kendall, CA Feghali-Bostwick - Frontiers in pharmacology, 2014 - frontiersin.org
Fibroblasts are the most common cell type of the connective tissues found throughout the
body and the principal source of the extensive extracellular matrix (ECM) characteristic of …
body and the principal source of the extensive extracellular matrix (ECM) characteristic of …
Autoantibodies in patients with chronic obstructive pulmonary disease
CA Feghali-Bostwick, AS Gadgil… - American journal of …, 2008 - atsjournals.org
Rationale: Adaptive immune responses are present in patients with chronic obstructive
pulmonary disease (COPD), and it has been postulated that these processes could be …
pulmonary disease (COPD), and it has been postulated that these processes could be …
Caveolin-1: a critical regulator of lung fibrosis in idiopathic pulmonary fibrosis
XM Wang, Y Zhang, HP Kim, Z Zhou… - The Journal of …, 2006 - rupress.org
Idiopathic pulmonary fibrosis (IPF) is a progressive chronic disorder characterized by
activation of fibroblasts and overproduction of extracellular matrix (ECM). Caveolin-1 (cav-1) …
activation of fibroblasts and overproduction of extracellular matrix (ECM). Caveolin-1 (cav-1) …
Partial inhibition of integrin αvβ6 prevents pulmonary fibrosis without exacerbating inflammation
GS Horan, S Wood, V Ona, DJ Li… - American journal of …, 2008 - atsjournals.org
Rationale: Transforming growth factor (TGF)-β has a central role in driving many of the
pathological processes that characterize pulmonary fibrosis. Inhibition of the integrin αvβ6, a …
pathological processes that characterize pulmonary fibrosis. Inhibition of the integrin αvβ6, a …
Comprehensive gene expression profiles reveal pathways related to the pathogenesis of chronic obstructive pulmonary disease
W Ning, CJ Li, N Kaminski… - Proceedings of the …, 2004 - National Acad Sciences
To better understand the molecular basis of chronic obstructive pulmonary disease (COPD),
we used serial analysis of gene expression (SAGE) and microarray analysis to compare the …
we used serial analysis of gene expression (SAGE) and microarray analysis to compare the …
Insulin-like growth factor binding proteins 3 and 5 are overexpressed in idiopathic pulmonary fibrosis and contribute to extracellular matrix deposition
JM Pilewski, L Liu, AC Henry, AV Knauer… - The American journal of …, 2005 - Elsevier
Idiopathic pulmonary fibrosis (IPF) is a fibrotic disease of unknown etiology that results in
significant morbidity and mortality. The pathogenesis of IPF is not completely understood …
significant morbidity and mortality. The pathogenesis of IPF is not completely understood …
Pulmonary involvement in systemic sclerosis: associations with genetic, serologic, sociodemographic, and behavioral factors
TA Mcnearney, JD Reveille, M Fischbach… - Arthritis Care & …, 2007 - Wiley Online Library
Objective To determine the relative contributions of genetic, clinical, serologic,
sociodemographic, and behavioral/psychological variables to early pulmonary involvement …
sociodemographic, and behavioral/psychological variables to early pulmonary involvement …
Cellular and humoral autoreactivity in idiopathic pulmonary fibrosis
CA Feghali-Bostwick, CG Tsai… - The Journal of …, 2007 - journals.aai.org
Idiopathic pulmonary fibrosis (IPF) is a morbid, refractory lung disorder with an unknown
pathogenesis. To investigate potential adaptive immune mechanisms in IPF, we compared …
pathogenesis. To investigate potential adaptive immune mechanisms in IPF, we compared …
The inflammasome activating caspase 1 mediates fibrosis and myofibroblast differentiation in systemic sclerosis
CM Artlett, S Sassi‐Gaha, JL Rieger… - Arthritis & …, 2011 - Wiley Online Library
Abstract Objective Systemic sclerosis (SSc) is a chronic idiopathic disease of unknown
etiology that is characterized by fibrosis of the skin and visceral organs mediated by …
etiology that is characterized by fibrosis of the skin and visceral organs mediated by …
Lung tissues in patients with systemic sclerosis have gene expression patterns unique to pulmonary fibrosis and pulmonary hypertension
E Hsu, H Shi, RM Jordan, J Lyons‐Weiler… - Arthritis & …, 2011 - Wiley Online Library
Objective Pulmonary complications, including pulmonary fibrosis (PF) and pulmonary
arterial hypertension (PAH), are the leading cause of mortality in patients with systemic …
arterial hypertension (PAH), are the leading cause of mortality in patients with systemic …