Recent studies have renewed the interest on the potential role that neutrophils play in the
development of systemic lupus erythematosus (SLE) and other autoimmune conditions. A …

Neutrophils are the most abundant leukocytes in circulation and represent one of the first
lines of defense against invading pathogens. Neutrophils possess a vast arsenal of …

The early events leading to the development of rheumatoid arthritis (RA) remain unclear, but
formation of autoantibodies to citrullinated protein antigens (ACPAs) is considered a key …

Neutrophil extracellular traps (NETs) are implicated in autoimmunity, but how they are
generated and their roles in sterile inflammation remain unclear. Ribonucleoprotein immune …

Background Adult-onset inflammatory syndromes often manifest with overlapping clinical
features. Variants in ubiquitin-related genes, previously implicated in autoinflammatory …

Neutrophil extracellular traps (NETs) represent an important defense mechanism against
microorganisms. Clearance of NETs is impaired in a subset of patients with systemic lupus …

Rationale The structural and functional integrity of the endothelium is crucial in maintaining
vascular homeostasis and preventing atherosclerosis. Patients with systemic lupus …

Systemic lupus erythematosus (SLE) is an autoimmune syndrome of unknown etiology,
characterized by multi-organ inflammation and clinical heterogeneity. SLE affects mostly …

Neutrophil infiltration is a hallmark of periodontitis, a prevalent oral inflammatory condition in
which Th17-driven mucosal inflammation leads to destruction of tooth-supporting bone …

Rheumatoid arthritis (RA) is characterized by synovial joint inflammation and by
development of pathogenic humoral and cellular autoimmunity to citrullinated proteins …