Mice lacking the dopamine transporter (DAT−/−) are characterized by high extracellular
dopamine levels and spontaneous hyperlocomotion. We performed a detailed analysis of …

Mice lacking the dopamine transporter (DAT) display biochemical and behavioural
dopaminergic hyperactivity despite dramatic alteration in dopamine homeostasis. In order to …

Metabolic changes drive monocyte differentiation and fate. Although abnormal mitochondria
metabolism and innate immune responses participate in the pathogenesis of many …

The activation of dopamine (DA) neurotransmission plays a crucial role in the behavioural
responses to drugs of abuse. In particular, increased extracellular levels of DA within the …

Rationale: Monocytes play critical roles in the pathogenesis of arthritis by contributing to the
inflammatory response and bone erosion. Among genes involved in regulating monocyte …

INTRODUCTION Mycobacterium tuberculosis (Mtb) is the leading global cause of lethal
infection in humans and accounts for the largest number of drug-resistant infections by a …

Rationale: Mice lacking the dopamine transporter (DAT–/–) exhibit high extracellular
dopamine levels and marked hyperactivity. This hyperlocomotion is paradoxically …

Microglial cells have a double life as the immune cells of the brain in times of stress but have
also specific physiological functions in homeostatic conditions. In pathological contexts …

Rising antimicrobial resistance challenges our ability to combat bacterial infections. The
problem is acute for tuberculosis (TB), the leading cause of death from infection before …

A newly validated target for tuberculosis treatment is phosphopantetheinyl transferase, an
essential enzyme that plays a critical role in the biosynthesis of cellular lipids and virulence …