The Clinical Pharmacogenetics Implementation Consortium (CPIC) publishes genotype-
based drug guidelines to help clinicians understand how available genetic test results could …

Rheumatoid arthritis affects about 1 percent of the US population and can cause irreversible
joint deformities and functional impairment. Although the cause of this autoimmune disease …

Ethnicity is an important demographic variable contributing to interindividual variability in
drug metabolism and response. In this rapidly expanding research area many genetic …

Background Users of typical antipsychotic drugs have an increased risk of serious
ventricular arrhythmias and sudden cardiac death. However, less is known regarding the …

Background Although several macrolide antibiotics are proarrhythmic and associated with
an increased risk of sudden cardiac death, azithromycin is thought to have minimal …

Background Premature coronary artery disease is a major cause of illness and death in
patients with systemic lupus erythematosus, but little is known about the prevalence, extent …

Background Genetic variants of the enzyme that metabolizes warfarin, cytochrome P-450
2C9 (CYP2C9), and of a key pharmacologic target of warfarin, vitamin K epoxide reductase …

Results of premarketing and postmarketing trials have raised doubts about the
cardiovascular safety of the non-steroidal anti-inflammatory drug (NSAID) rofecoxib …

Background Oral erythromycin prolongs cardiac repolarization and is associated with case
reports of torsades de pointes. Because erythromycin is extensively metabolized by …

Tacrolimus is the mainstay immunosuppressant drug used after solid organ and
hematopoietic stem cell transplantation. Individuals who express CYP3A5 (extensive and …