Sensors of the innate immune system: their mode of action
The discovery of molecular sensors that enable eukaryotes to recognize microbial
pathogens and their products has been a key advance in our understanding of innate …
pathogens and their products has been a key advance in our understanding of innate …
Sensors of the innate immune system: their link to rheumatic diseases
AN Theofilopoulos, R Gonzalez-Quintial… - Nature Reviews …, 2010 - nature.com
Evidence strongly suggests that excessive or protracted signaling, or both, by cell-surface or
intracellular innate immune receptors is central to the pathogenesis of most autoimmune …
intracellular innate immune receptors is central to the pathogenesis of most autoimmune …
A regenerative approach to the treatment of multiple sclerosis
VA Deshmukh, V Tardif, CA Lyssiotis, CC Green… - Nature, 2013 - nature.com
Progressive phases of multiple sclerosis are associated with inhibited differentiation of the
progenitor cell population that generates the mature oligodendrocytes required for …
progenitor cell population that generates the mature oligodendrocytes required for …
[HTML][HTML] T cell homeostatic proliferation elicits effective antitumor autoimmunity
W Dummer, AG Niethammer, R Baccala… - The Journal of …, 2002 - Am Soc Clin Investig
Development of tumor immunotherapies focuses on inducing autoimmune responses
against tumor-associated self-antigens primarily encoded by normal, unmutated genes. We …
against tumor-associated self-antigens primarily encoded by normal, unmutated genes. We …
[HTML][HTML] The role of IFN-gamma in systemic lupus erythematosus: a challenge to the Th1/Th2 paradigm in autoimmunity
AN Theofilopoulos, S Koundouris, DH Kono… - Arthritis Research & …, 2001 - Springer
The classification of T helper cells into type 1 (Th1) and type 2 (Th2) led to the hypothesis
that Th1 cells and their cytokines (interleukin [IL]-2, interferon [IFN]-γ) are involved in cell …
that Th1 cells and their cytokines (interleukin [IL]-2, interferon [IFN]-γ) are involved in cell …
Endosomal TLR signaling is required for anti-nucleic acid and rheumatoid factor autoantibodies in lupus
DH Kono, MK Haraldsson… - Proceedings of the …, 2009 - National Acad Sciences
Using the Unc93b1 3d mutation that selectively abolishes nucleic acid-binding Toll-like
receptor (TLR)(TLR3,-7,-9) signaling, we show these endosomal TLRs are required for …
receptor (TLR)(TLR3,-7,-9) signaling, we show these endosomal TLRs are required for …
Toll-like receptors and their role in renal pathologies
T Eleftheriadis, G Pissas, V Liakopoulos… - … & Allergy-Drug …, 2012 - ingentaconnect.com
Toll-like receptors (TLRs) are the first identified and best studied family of pattern recognition
receptors. Expressed in immunocytes, TLRs initiate innate immune responses and …
receptors. Expressed in immunocytes, TLRs initiate innate immune responses and …
Anti–IFN-α/β Receptor Antibody Treatment Ameliorates Disease in Lupus-Predisposed Mice
R Baccala, R Gonzalez-Quintial… - The Journal of …, 2012 - journals.aai.org
The demonstration in humans and mice that nucleic acid-sensing TLRs and type I IFNs are
essential disease mediators is a milestone in delineating the mechanisms of lupus …
essential disease mediators is a milestone in delineating the mechanisms of lupus …
An immunosuppressive antibody–drug conjugate
We have developed a novel antibody–drug conjugate (ADC) that can selectively deliver the
Lck inhibitor dasatinib to human T lymphocytes. This ADC is based on a humanized …
Lck inhibitor dasatinib to human T lymphocytes. This ADC is based on a humanized …
Inflammation and autoimmunity caused by a SHP1 mutation depend on IL-1, MyD88, and a microbial trigger
A recessive phenotype called spin (spontaneous inflammation) was induced by N-ethyl-N-
nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic …
nitrosourea (ENU) mutagenesis in C57BL/6J mice. Homozygotes display chronic …