Highlights•Atypical B cells (ABCs) are expanded in malaria and autoimmune
diseases..•ABCs are similar in malaria and SLE but likely play disease-specific roles.•They …

Two seminal observations suggest that the African genome contains genes selected by
malaria that protect against systemic lupus erythematosus (SLE) in individuals chronically …

B-1 B cells derive from a developmental program distinct from that of conventional B cells,
through B cell receptor (BCR)-dependent positive selection of fetally derived precursors …

The discovery that Africans were resistant to infection by Plasmodium vivax (P. vivax) led to
the conclusion that P. vivax invasion relied on the P. vivax Duffy Binding Protein (PvDBP) …

To the Editor: Autosomal dominant hyper-IgE syndrome (AD-HIES) is a rare primary
immunodeficiency caused by dominant negative loss-of-function (LOF) mutations in signal …

There has been a sharp rise in allergic asthma and asthma-related deaths in the developed
world, in contrast to many childhood illnesses that have been reduced or eliminated. The …

Background Monogenic autoinflammatory diseases (AID) are caused by mutations in innate
immune genes. The effects of these mutations on allergic inflammation are unknown …

Cathelicidins are a family of cationic peptides expressed in mammals that possess
numerous bactericidal and immunomodulatory properties. In vitro analyses showed that …

Environmental factors and host microbiota strongly influence type 1 diabetes (T1D)
progression. We report that neonatal immunization with group A Streptococcus suppresses …

Background and objective Evidence for the treatment of multisystem inflammatory syndrome
in children (MIS-C) is lacking. Anakinra, which targets IL-1-mediated inflammation, is …