Background Our objective was to develop an instrument to assess the methodological
quality of systematic reviews, building upon previous tools, empirical evidence and expert …

Objective To develop ROBIS, a new tool for assessing the risk of bias in systematic reviews
(rather than in primary studies). Study Design and Setting We used four-stage approach to …

Background Osteoarthritis (OA) is a common form of arthritis and is often associated with
significant disability and impaired quality of life. This is an update of a Cochrane review first …

The number of published systematic reviews of studies of healthcare interventions has
increased rapidly and these are used extensively for clinical and policy decisions …

The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of Nonrandomized Studies in
Meta- Analysis Page 1 The Newcastle-Ottawa Scale (NOS) for Assessing the Quality of …

OBJECTIVE: Our purpose was to measure the agreement, reliability, construct validity, and
feasibility of a measurement tool to assess systematic reviews (AMSTAR). STUDY DESIGN …

Background Osteoporosis is a condition resulting in an increased risk of skeletal fractures
due to a reduction in the density of bone tissue. Treatment of osteoporosis typically involves …

Background Thousands of systematic reviews have been conducted in all areas of health
care. However, the methodological quality of these reviews is variable and should routinely …

Background Osteoporosis is a condition resulting in an increased risk of skeletal fractures
due to a reduction in the density of bone tissue. Prevention of osteoporotic-related fractures …

Background Methotrexate (MTX) is a disease modifying antirheumatic drug (DMARD) used
as a first line agent for treating rheumatoid arthritis (RA). Pharmacologically, it is classified as …