After the approval of bosentan for the treatment of pulmonary arterial hypertension (PAH),
European authorities required the introduction of a post-marketing surveillance system …

Abstract Background Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease
characterized by progressive neurodegeneration and premature death. We report data …

Although sleep deprivation is known to exert an antidepressant effect in depressed patients,
the involvement of sleep regulation is still unknown. Selective sleep deprivation experiments …

To study the role of adenosine in sleep regulation, the adenosine A1 receptor agonist N6-
cyclopentyladenosine (CPA) and the antagonist caffeine were administered to rats …

Objectives The Digital Ulcers Outcome (DUO) Registry was designed to describe the clinical
and antibody characteristics, disease course and outcomes of patients with digital ulcers …

Objectives Digital ulcers (DUs) occur in up to half of patients with systemic sclerosis (SSc)
and may lead to infection, gangrene and amputation with functional disability and reduced …

The oral dual endothelin receptor antagonist bosentan has been shown to improve the short-
and medium-term course of adult pulmonary arterial hypertension (PAH); however, data …

Abstract Background Niemann-Pick disease type C (NP-C) is a rare neurovisceral disease
characterised by progressive neurological degeneration, where the rate of neurological …

OBJECTIVES: Digital ulcers (DUs) are frequent manifestations of systemic scleroderma
(SSc). This study assessed functional limitations due to DUs among patients enrolled in the …

To investigate whether sleep homeostasis in the female rat is modulated by the estrous
cycle, the vigilance states, EEG power spectra and cortical temperature (TCRT) were …