Continued improvements in cancer therapies have increased the number of long-term
cancer survivors. Radiation therapy remains one of the primary treatment modalities with …

Current therapies for nerve regeneration within injured tissues have had limited success due
to complicated neural anatomy and inhibitory barriers in situ. Recent advancements in 3D …

Aging and age-related neurodegeneration are both associated with the accumulation of
unfolded and abnormally folded proteins, highlighting the importance of protein homeostasis …

The conformational change of a host protein, PrPC, into a disease-associated isoform,
PrPSc, appears to play a critical role in the pathogenesis of prion diseases such as …

Immune exclusion predicts poor patient outcomes in multiple malignancies, including triple-
negative breast cancer (TNBC). The extracellular matrix (ECM) contributes to immune …

Most cancer cells are characterized by aneuploidy, an abnormal number of chromosomes.
We have identified a clue to the mechanistic origins of aneuploidy through integrative …

Object Accurate discrimination between tumor and normal tissue is crucial for optimal tumor
resection. Qualitative fluorescence of protoporphyrin IX (PpIX), synthesized endogenously …

Object The aim of this study was to investigate the relationships between intraoperative
fluorescence, features on MR imaging, and neuropathological parameters in 11 cases of …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by
the progressive loss of motor neurons. While several pathogenic mutations have been …

Cholesterol metabolism has been implicated in the pathogenesis of several
neurodegenerative diseases, including the abnormal accumulation of amyloid-β, one of the …