Efficient− 2 frameshifting by mammalian ribosomes to synthesize an additional arterivirus protein

Y Fang, EE Treffers, Y Li, A Tas, Z Sun… - proceedings of the …, 2012 - National Acad Sciences
Programmed− 1 ribosomal frameshifting (− 1 PRF) is a gene-expression mechanism used to
express many viral and some cellular genes. In contrast, efficient natural utilization of− 2 …

[HTML][HTML] Mutated nucleophosmin 1 as immunotherapy target in acute myeloid leukemia

DI van der Lee, RM Reijmers… - The Journal of …, 2019 - Am Soc Clin Investig
The most frequent subtype of acute myeloid leukemia (AML) is defined by mutations in the
nucleophosmin 1 (NPM1) gene. Mutated NPM1 (ΔNPM1) is an attractive target for …

PRAME-specific allo-HLA–restricted T cells with potent antitumor reactivity useful for therapeutic T-cell receptor gene transfer

AL Amir, DM van der Steen, MM van Loenen… - Clinical Cancer …, 2011 - AACR
Purpose: In human leukocyte antigen (HLA)–matched stem cell transplantation (SCT), it has
been shown that beneficial immune response mediating graft-versus-tumor (GVT) …

[HTML][HTML] The human leukocyte antigen–presented ligandome of B lymphocytes

C Hassan, MGD Kester, AH de Ru, P Hombrink… - Molecular & Cellular …, 2013 - ASBMB
Peptides presented by human leukocyte antigen (HLA) molecules on the cell surface play a
crucial role in adaptive immunology, mediating the communication between T cells and …

Multimodal Mass Spectrometry Imaging of N-Glycans and Proteins from the Same Tissue Section

B Heijs, S Holst, IH Briaire-de Bruijn… - Analytical …, 2016 - ACS Publications
On-tissue digestion matrix-assisted laser desorption/ionization mass spectrometry imaging
(MALDI-MSI) can be used to record spatially correlated molecular information from formalin …

MiR-17/20/93/106 promote hematopoietic cell expansion by targeting sequestosome 1–regulated pathways in mice

A Meenhuis, PA van Veelen… - Blood, The Journal …, 2011 - ashpublications.org
MicroRNAs (miRNAs) are pivotal for regulation of hematopoiesis but their critical targets
remain largely unknown. Here, we show that ectopic expression of miR-17,-20,-93 and-106 …

Alternative peptide repertoire of HLA-E reveals a binding motif that is strikingly similar to HLA-A2

MH Lampen, C Hassan, M Sluijter, A Geluk… - Molecular …, 2013 - Elsevier
The non-classical HLA-E is a conserved class I molecule that mainly presents monomorphic
leader peptides derived from other HLA class I molecules. These leader peptides comprise …

[HTML][HTML] Naturally processed non-canonical HLA-A* 02: 01 presented peptides

C Hassan, E Chabrol, L Jahn, MGD Kester… - Journal of Biological …, 2015 - ASBMB
Human leukocyte antigen (HLA) class I molecules generally present peptides (p) of 8 to 11
amino acids (aa) in length. Although an increasing number of examples with lengthy (> 11 …

Morphological changes during dendritic cell maturation correlate with cofilin activation and translocation to the cell membrane

P Verdijk, PA van Veelen, AH de Ru… - European journal of …, 2004 - Wiley Online Library
Upon activation, tissue residing immature dendritic cells (DC) start to migrate towards the
draining lymph node and mature into efficient antigen‐presenting cells. During maturation …

[HTML][HTML] ST6Gal1 targets the ectodomain of ErbB2 in a site-specific manner and regulates gastric cancer cell sensitivity to trastuzumab

HO Duarte, JG Rodrigues, C Gomes, PJ Hensbergen… - Oncogene, 2021 - nature.com
The clinical performance of the therapeutic monoclonal antibody trastuzumab in the
treatment of ErbB2-positive unresectable gastric cancer (GC) is severely hampered by the …