T cell immunity is central for the control of viral infections. To characterize T cell immunity,
but also for the development of vaccines, identification of exact viral T cell epitopes is …

Immunotherapies, particularly checkpoint inhibitors, have set off a revolution in cancer
therapy by releasing the power of the immune system. However, only little is known about …

We present a novel mass spectrometry-based high-throughput workflow and an open-
source computational and data resource to reproducibly identify and quantify HLA …

Objectives Interferon (IFN) α is a key immunoregulatory cytokine secreted by activated
plasmacytoid dendritic cells (PDC) that constitute less than 1% of leucocytes. IFNα plays an …

Poor graft function (PGF) is a severe complication of haematopoietic stem cell
transplantation (HSCT) and administration of donor stem cell boosts (SCB s) represents a …

Background Medulloblastoma is the most common malignant brain tumor in childhood and
adolescence. Although some patients present with distinct genetic alterations, such as …

Chimeric antigen receptor (CAR)-T therapy holds great promise to sustainably improve
cancer treatment. However, currently, a broad applicability of CAR-T cell therapies is …

Haploidentical stem cell transplantation (haplo SCT) in Stage IV neuroblastoma relapsed
patients has been proven efficacious, while immunotherapy utilizing the anti-GD2 antibody …

Localized prostate cancer is curable, but metastatic castration sensitive prostate cancer has
a low 5-year survival rate, while broad treatment options are lacking. Here we present an …

Anti-T lymphocyte globulin (ATLG) significantly reduces the risk of engraftment failure in
allogeneic hematopoietic stem cell transplantation (HSCT), but hampers post-transplant …