[HTML][HTML] Porphyromonas gingivalis Facilitates the Development and Progression of Destructive Arthritis through Its Unique Bacterial Peptidylarginine Deiminase (PAD …
KJ Maresz, A Hellvard, A Sroka, K Adamowicz… - PLoS …, 2013 - journals.plos.org
Rheumatoid arthritis and periodontitis are two prevalent chronic inflammatory diseases in
humans and are associated with each other both clinically and epidemiologically. Recent …
humans and are associated with each other both clinically and epidemiologically. Recent …
[HTML][HTML] Citrullination of autoantigens: upstream of TNFα in the pathogenesis of rheumatoid arthritis
AM Quirke, BAC Fisher, AJ Kinloch, PJ Venables - FEBS letters, 2011 - Elsevier
Rheumatoid arthritis (RA) is a chronic autoimmune disease characterised by synovial
inflammation and destruction of joints. Over 20years ago, tumour necrosis factor alpha …
inflammation and destruction of joints. Over 20years ago, tumour necrosis factor alpha …
Heightened immune response to autocitrullinated Porphyromonas gingivalis peptidylarginine deiminase: a potential mechanism for breaching immunologic tolerance …
AM Quirke, EB Lugli, N Wegner, BC Hamilton… - Annals of the …, 2014 - ard.bmj.com
Background Rheumatoid arthritis (RA) is characterised by autoimmunity to citrullinated
proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis …
proteins, and there is increasing epidemiologic evidence linking Porphyromonas gingivalis …
Antibodies to Porphyromonas gingivalis Indicate Interaction Between Oral Infection, Smoking, and Risk Genes in Rheumatoid Arthritis Etiology
N Kharlamova, X Jiang, N Sherina… - Arthritis & …, 2016 - Wiley Online Library
Objective To investigate the role of the periodontal pathogen Porphyromonas gingivalis in
the etiology of rheumatoid arthritis (RA) by analyzing the antibody response to the P …
the etiology of rheumatoid arthritis (RA) by analyzing the antibody response to the P …
Influence of periodontal disease, Porphyromonas gingivalis and cigarette smoking on systemic anti‐citrullinated peptide antibody titres
DF Lappin, D Apatzidou, AM Quirke… - Journal of clinical …, 2013 - Wiley Online Library
Background Anti‐citrullinated protein antibody (ACPA) responses may precede clinical
onset of rheumatoid arthritis. Porphyromonas gingivalis peptidylarginine deiminase can …
onset of rheumatoid arthritis. Porphyromonas gingivalis peptidylarginine deiminase can …
[HTML][HTML] Abrogation of collagen-induced arthritis by a peptidyl arginine deiminase inhibitor is associated with modulation of T cell-mediated immune responses
J Kawalkowska, AM Quirke, F Ghari, S Davis… - Scientific reports, 2016 - nature.com
Proteins containing citrulline, a post-translational modification of arginine, are generated by
peptidyl arginine deiminases (PAD). Citrullinated proteins have pro-inflammatory effects in …
peptidyl arginine deiminases (PAD). Citrullinated proteins have pro-inflammatory effects in …
Evolutionary Genetic Analysis of the Emergence of Epidemic Vibrio cholerae Isolates on the Basis of Comparative Nucleotide Sequence Analysis and Multilocus …
YA O'shea, FJ Reen, AM Quirke… - Journal of clinical …, 2004 - Am Soc Microbiol
Vibrio cholerae, the causative agent of cholera, is a natural inhabitant of the aquatic
ecosystem. We examined a unique collection of V. cholerae clinical and environmental …
ecosystem. We examined a unique collection of V. cholerae clinical and environmental …
[PDF][PDF] Bronchiectasis is a model for chronic bacterial infection inducing autoimmunity in rheumatoid arthritis
AM Quirke, E Perry, A Cartwright, C Kelly… - Arthritis & …, 2015 - Wiley Online Library
Objective To examine the potential of chronic severe bacterial infection to generate
rheumatoid factor (RF) and anti–citrullinated protein antibodies (ACPAs), by studying …
rheumatoid factor (RF) and anti–citrullinated protein antibodies (ACPAs), by studying …
Identification of an immunodominant peptide from citrullinated tenascin-C as a major target for autoantibodies in rheumatoid arthritis
Objectives We investigated whether citrullinated tenascin-C (cTNC), an extracellular matrix
protein expressed at high levels in the joints of patients with rheumatoid arthritis (RA), is a …
protein expressed at high levels in the joints of patients with rheumatoid arthritis (RA), is a …
[HTML][HTML] Combination of enzymes and rutin to manage osteoarthritis symptoms: Lessons from a narrative review of the literature
YE Henrotin, C Michlmayr, SM Rau, AM Quirke… - Rheumatology and …, 2022 - Springer
Osteoarthritis is the most common joint disorder affecting over 300 million people worldwide.
It typically affects the knees and the hips, and is characterized by a loss in normal joint …
It typically affects the knees and the hips, and is characterized by a loss in normal joint …