Inflammasomes are large cytosolic multiprotein complexes assembled in response to
infection and cellular stress, and are crucial for the activation of inflammatory caspases and …

Inflammasomes represent molecular platforms for the activation of inflammatory caspases
and are essential for processing and secretion of the inflammatory cytokines IL-1β and IL-18 …

Cytosolic pattern recognition receptors (PRRs) sense a wide range of endogenous danger-
associated molecular patterns as well as exogenous pathogen-associated molecular …

Hemostasis initiates angiogenesis-dependent wound healing, and thrombosis is frequently
associated with advanced cancer. Although activation of coagulation generates potent …

Cytosolic pathogen-and damage-associated molecular patterns are sensed by pattern
recognition receptors, including members of the nucleotide-binding domain and leucine-rich …

Activation of caspase 1 is essential for the maturation and release of IL-1β and IL-18 and
occurs in multiprotein complexes, referred to as inflammasomes. The apoptosis-associated …

Apoptosis-associated speck-like protein containing a caspase recruitment domain
(ASC)/target of methylation-induced silencing/PYCARD represents one of only two proteins …

Rheumatoid arthritis (RA) is a chronic systemic inflammatory disease which is in part
mediated by the migration of monocytes from blood to RA synovial tissue, where they …

The innate immune system responds to infection and tissue damage by activating cytosolic
sensory complexes called'inflammasomes'. Cytosolic DNA is sensed by AIM2-like receptors …

Lipopolysaccharide (LPS) of Gram-negative bacteria can elicit a strong immune response.
Although extracellular LPS is sensed by TLR4 at the cell surface and triggers a …