IL-1β is a proinflammatory mediator with roles in innate and adaptive immunity. Here we
show that IL-1β contributes to autoimmune arthritis by inducing osteoclastogenic capacity in …

Rheumatoid arthritis is a systemic autoimmune disease, but disease flares typically affect
only a subset of joints, distributed in a distinctive pattern for each patient. Pursuing this …

Bone marrow megakaryocytes engulf neutrophils in a phenomenon termed emperipolesis.
We show here that emperipolesis is a dynamic process mediated actively by both lineages …

Still's disease is a severe inflammatory syndrome characterized by fever, skin rash and
arthritis affecting children and adults. Patients with Still's disease may also develop …

Objective Macrophage activation syndrome (MAS) is a life-threatening complication of
systemic juvenile idiopathic arthritis (sJIA) characterised by a vicious cycle of immune …

Objective Neutrophils are typically the most abundant leucocyte in arthritic synovial fluid. We
sought to understand changes that occur in neutrophils as they migrate from blood to joint …

TRAF1/C5 was among the first loci shown to confer risk for inflammatory arthritis in the
absence of an associated coding variant, but its genetic mechanism remains undefined …