User profiles for "author:Adriano Taddeo"

Adriano Taddeo

Institute of Virology and Immunology , Swiss Confederation
Verified email at ivi.admin.ch
Cited by 2493

[HTML][HTML] SARS-CoV-2 spike D614G change enhances replication and transmission

B Zhou, TTN Thao, D Hoffmann, A Taddeo, N Ebert… - Nature, 2021 - nature.com
During the evolution of SARS-CoV-2 in humans, a D614G substitution in the spike
glycoprotein (S) has emerged; virus containing this substitution has become the …

The proteasome inhibitior bortezomib depletes plasma cells and ameliorates clinical manifestations of refractory systemic lupus erythematosus

T Alexander, R Sarfert, J Klotsche, AA Kühl… - Annals of the …, 2015 - ard.bmj.com
Objectives To investigate whether bortezomib, a proteasome inhibitor approved for
treatment of multiple myeloma, induces clinically relevant plasma cell (PC) depletion in …

Point-of-care therapeutic drug monitoring for precision dosing of immunosuppressive drugs

A Taddeo, D Prim, ED Bojescu… - The journal of …, 2020 - academic.oup.com
Background Immunosuppressive drugs (ISD) are an essential tool in the treatment of
transplant rejection and immune-mediated diseases. Therapeutic drug monitoring (TDM) for …

[HTML][HTML] The spike gene is a major determinant for the SARS-CoV-2 Omicron-BA. 1 phenotype

GT Barut, NJ Halwe, A Taddeo, JN Kelly… - Nature …, 2022 - nature.com
Variant of concern (VOC) Omicron-BA. 1 has achieved global predominance in early 2022.
Therefore, surveillance and comprehensive characterization of Omicron-BA. 1 in advanced …

Human defensins activate monocyte-derived dendritic cells, promote the production of proinflammatory cytokines, and up-regulate the surface expression of CD91

P Presicce, S Giannelli, A Taddeo… - Journal of leukocyte …, 2009 - academic.oup.com
Immunostimulatory properties of defensins on DC promote maturation and proinflammatory
response. Defensins are endogenous defense peptides with well-defined antimicrobial …

[HTML][HTML] Enhanced fitness of SARS-CoV-2 variant of concern Alpha but not Beta

L Ulrich, NJ Halwe, A Taddeo, N Ebert, J Schön… - Nature, 2022 - nature.com
Emerging variants of concern (VOCs) are driving the COVID-19 pandemic,. Experimental
assessments of replication and transmission of major VOCs and progenitors are needed to …

[PDF][PDF] Stromal cell-contact dependent PI3K and APRIL induced NF-κB signaling prevent mitochondrial-and ER stress induced death of memory plasma cells

R Cornelis, S Hahne, A Taddeo, G Petkau, D Malko… - Cell reports, 2020 - cell.com
The persistence of long-lived memory plasma cells in the bone marrow depends on survival
factors available in the bone marrow, which are provided in niches organized by stromal …

[HTML][HTML] SARS-CoV-2 spike D614G variant confers enhanced replication and transmissibility

B Zhou, TTN Thao, D Hoffmann, A Taddeo, N Ebert… - BioRxiv, 2020 - ncbi.nlm.nih.gov
During the evolution of SARS-CoV-2 in humans a D614G substitution in the spike (S) protein
emerged and became the predominant circulating variant (S-614G) of the COVID-19 …

[HTML][HTML] Perfusion-decellularization of human ear grafts enables ECM-based scaffolds for auricular vascularized composite tissue engineering

J Duisit, H Amiel, T Wüthrich, A Taddeo, A Dedriche… - Acta biomaterialia, 2018 - Elsevier
Introduction: Human ear reconstruction is recognized as the emblematic enterprise in tissue
engineering. Up to now, it has failed to reach human applications requiring appropriate …

[HTML][HTML] Long-lived plasma cells are early and constantly generated in New Zealand Black/New Zealand White F1 mice and their therapeutic depletion requires a …

A Taddeo, L Khodadadi, C Voigt, IM Mumtaz… - Arthritis research & …, 2015 - Springer
Introduction Autoantibodies contribute significantly to the pathogenesis of systemic lupus
erythematosus (SLE). Unfortunately, the long-lived plasma cells (LLPCs) secreting such …