Signal transduction down the Ras/MAPK pathway, including that critical to T cell activation,
proliferation, and differentiation, has been generally considered to occur at the plasma …

Although multiple cell types are present in the rheumatoid joint, the fibroblast-like synovial
cell (FLS) is among the most prominent. It is now appreciated that the FLS is not only space …

Abstract Programmed death-1 (PD-1) is a co-receptor that is expressed predominantly by T
cells. The binding of PD-1 to its ligands, PD-L1 or PD-L2, is vital for the physiologic …

K-Ras associates with the plasma membrane (PM) through farnesylation that functions in
conjunction with an adjacent polybasic sequence. We show that phosphorylation by protein …

OBJECTIVE: To establish a new, objective, statistically based severity score for familial
Mediterranean fever (FMF). METHODS: One hundred consecutive FMF patients were …

Familial Mediterranean fever (FMF) is a hereditary epidosic febrile syndrome that is
expressed by acute spells of fever, painful manifestations in the abdomen, chest and joints …

Programmed cell death-1 (PD-1) is an essential inhibitory receptor in T cells. Antibodies
targeting PD-1 elicit durable clinical responses in patients with multiple tumor indications …

PD-1 is an inhibitory receptor in T cells, and antibodies that block its interaction with ligands
augment anti-tumor immune responses. The clinical potential of these agents is limited by …

Programmed cell death protein 1 (PD-1) is an inhibitory receptor on T lymphocytes that is
critical for modulating adaptive immunity. As such, it has been successfully exploited for …

Close physical proximity between mast cells and T cells has been demonstrated in several T
cell-mediated inflammatory processes. However, the way by which mast cells are activated …