User profiles for "author:Achilleas Floudas"
Achilleas FloudasAssistant Professor Dublin City University Verified email at dcu.ie Cited by 1378 |
Cellular metabolic adaptations in rheumatoid arthritis and their therapeutic implications
Activation of endothelium and immune cells is fundamental to the initiation of autoimmune
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …
diseases such as rheumatoid arthritis (RA), and it results in trans-endothelial cell migration …
[HTML][HTML] The PD-1: PD-L1 axis in inflammatory arthritis
The activation of antigen specific T cells during an immune response is a tightly regulated
process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory …
process at the level of both costimulatory and coinhibitory receptors. One such coinhibitory …
[HTML][HTML] PD-L1hi B cells are critical regulators of humoral immunity
Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B
cells (Breg). The majority of Breg cells described in mouse and man have been identified by …
cells (Breg). The majority of Breg cells described in mouse and man have been identified by …
New insights into IL-10 dependent and IL-10 independent mechanisms of regulatory B cell immune suppression
Regulatory B (Breg) cells are important regulators of immune responses and in recent years
our understanding of their phenotypical and functional characteristics has improved …
our understanding of their phenotypical and functional characteristics has improved …
[HTML][HTML] Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity
SP Saunders, T Moran, A Floudas, F Wurlod… - Journal of Allergy and …, 2016 - Elsevier
Background Atopic dermatitis (AD) is an inflammatory skin condition that can occur in early
life, predisposing to asthma development in a phenomenon known as the atopic march …
life, predisposing to asthma development in a phenomenon known as the atopic march …
ILC2s regulate adaptive Th2 cell functions via PD-L1 checkpoint control
Group 2 innate lymphoid cells (ILC2s) are important effector cells driving the initiation of type
2 immune responses leading to adaptive T helper 2 (Th2) immunity. Here we show that …
2 immune responses leading to adaptive T helper 2 (Th2) immunity. Here we show that …
[HTML][HTML] Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint
While autoantibodies are used in the diagnosis of rheumatoid arthritis (RA), the function of B
cells in the inflamed joint remains elusive. Extensive flow cytometric characterization and …
cells in the inflamed joint remains elusive. Extensive flow cytometric characterization and …
[HTML][HTML] Serum miRNA signature in rheumatoid arthritis and “at-risk individuals”
CC Cunningham, S Wade, A Floudas, C Orr… - Frontiers in …, 2021 - frontiersin.org
Background MicroRNAs (miRNAs) are small non-coding RNAs which have been implicated
as potential biomarkers or therapeutic targets in autoimmune diseases. This study examines …
as potential biomarkers or therapeutic targets in autoimmune diseases. This study examines …
[HTML][HTML] CD209/CD14+ dendritic cells characterization in rheumatoid and psoriatic arthritis patients: activation, synovial infiltration, and therapeutic targeting
Dendritic cells (DC) have a key role in the initiation and progression of inflammatory arthritis
(IA). In this study, we identified a DC population that derive from monocytes, characterized …
(IA). In this study, we identified a DC population that derive from monocytes, characterized …
Spontaneous atopic dermatitis in mice with a defective skin barrier is independent of ILC2 and mediated by IL‐1β
C Schwartz, T Moran, SP Saunders, A Kaszlikowska… - Allergy, 2019 - Wiley Online Library
Background Atopic dermatitis (AD) is one of the most common skin diseases with a
multifactorial etiology. Mutations leading to loss of skin barrier function are associated with …
multifactorial etiology. Mutations leading to loss of skin barrier function are associated with …