DHEA Metabolism in Arthritis: A Role for the p450 Enzyme Cyp7b at the Immune–Endocrine Crossroad
J Dulos, AH Boots - Annals of the New York Academy of …, 2006 - Wiley Online Library
For dehydroepiandrosterone (DHEA) both immunosuppressive and immuno‐stimulating
properties have been described. The immunosuppressive effects may be explained by the …
properties have been described. The immunosuppressive effects may be explained by the …
Melanoma inhibitory activity, a biomarker related to chondrocyte anabolism, is reversibly suppressed by proinflammatory cytokines in rheumatoid arthritis
B Vandooren, T Cantaert, MJ van Lierop… - Annals of the …, 2009 - ard.bmj.com
Objective: In mice, melanoma inhibitory activity (MIA) is a chondrocyte-specific molecule with
similar regulation to collagen type II. As MIA is a small secreted protein, its value as cartilage …
similar regulation to collagen type II. As MIA is a small secreted protein, its value as cartilage …
THU0025 Effect of Ageing on Anti-Mpo Antibody Mediated Glomerulonephritis in Mice
Q Wang, MM van Timmeren, AH Petersen, J Yuan… - 2015 - ard.bmj.com
Background Antineutrophil cytoplasmic antibodies (ANCA)-associated vasculitis (AAV) is a
typical disease of the elderly. In AAV there is an age-specific increase in disease incidence …
typical disease of the elderly. In AAV there is an age-specific increase in disease incidence …
T cell lessons from the RA synovium SCID mouse model: synovial tissue rich in CD3 T cells lacks response to CTLA4-Ig, but is successfully treated with anti-IL-17 …
MI Koenders, RJ Marijnissen… - Annals of the …, 2011 - ard.bmj.com
Background Target discovery and drug development is a very time consuming and
expensive process, which is partly due to the fact that preclinical findings from animal …
expensive process, which is partly due to the fact that preclinical findings from animal …
Aged T cell subsets are characterized by a distinct microRNA signature
N Teteloshvili, A Van Den Berg… - … of Immunology (ICI) …, 2013 - frontiersin.org
Objective Decline of immunological responsiveness in elderly correlates with changes in the
composition of the T cell compartment. Recently, microRNAs (miRNA) have emerged as …
composition of the T cell compartment. Recently, microRNAs (miRNA) have emerged as …
[CITATION][C] cited by Comroe
AH Boots - BI: Arthritis and Allied Conditions, Philadelphia, Lea & …, 1944