User profiles for "author:A Dudek"

Arkadiusz Z DUDEK

Professor of Oncology, Mayo Clinic
Verified email at mayo.edu
Cited by 10838

Pericytes and vessel maturation during tumor angiogenesis and metastasis

A Raza, MJ Franklin, AZ Dudek - American journal of …, 2010 - Wiley Online Library
Despite promising results in preclinical and clinical studies, the therapeutic efficacy of
antiangiogenic therapies has been restricted by a narrow focus on inhibiting the growth of …

Computational methods in developing quantitative structure-activity relationships (QSAR): a review

AZ Dudek, T Arodz, J Gálvez - Combinatorial chemistry & high …, 2006 - ingentaconnect.com
Virtual filtering and screening of combinatorial libraries have recently gained attention as
methods complementing the high-throughput screening and combinatorial chemistry. These …

[HTML][HTML] Immature, semi-mature, and fully mature dendritic cells: toward a DC-cancer cells interface that augments anticancer immunity

AM Dudek, S Martin, AD Garg, P Agostinis - Frontiers in immunology, 2013 - frontiersin.org
Dendritic cells (DCs) are the sentinel antigen-presenting cells of the immune system; such
that their productive interface with the dying cancer cells is crucial for proper communication …

EV-TRACK: transparent reporting and centralizing knowledge in extracellular vesicle research

…, V Depoorter, B Dhondt, TAP Driedonks, A Dudek… - Nature …, 2017 - nature.com
We argue that the field of extracellular vesicle (EV) biology needs more transparent
reporting to facilitate interpretation and replication of experiments. To achieve this, we …

[HTML][HTML] Origin of endothelial progenitors in human postnatal bone marrow

M Reyes, A Dudek, B Jahagirdar… - The Journal of …, 2002 - Am Soc Clin Investig
This study demonstrates that a CD34–, vascular endothelial cadherin–(VE-cadherin–),
AC133+, and fetal liver kinase+ (Flk1+) multipotent adult progenitor cell (MAPC) that …

Efficacy and safety of tofacitinib monotherapy, tofacitinib with methotrexate, and adalimumab with methotrexate in patients with rheumatoid arthritis (ORAL Strategy): a …

R Fleischmann, E Mysler, S Hall, AJ Kivitz, RJ Moots… - The Lancet, 2017 - thelancet.com
Background Tofacitinib is an oral Janus kinase inhibitor for the treatment of rheumatoid
arthritis. The Oral Rheumatoid Arthritis triaL (ORAL) Strategy aimed to assess the …

Afatinib for patients with lung adenocarcinoma and epidermal growth factor receptor mutations (LUX-Lung 2): a phase 2 trial

JCH Yang, JY Shih, WC Su, TC Hsia, CM Tsai… - The lancet …, 2012 - thelancet.com
Background Afatinib is an irreversible ErbB-family blocker with preclinical activity in non-
small-cell lung cancer (NSCLC) with EGFR mutations. We aimed to assess the efficacy of …

Ixekizumab, an interleukin-17A antagonist in the treatment of ankylosing spondylitis or radiographic axial spondyloarthritis in patients previously untreated with …

…, A Rubbert-Roth, M Szymanska, T Blicharski, A Dudek… - The Lancet, 2018 - thelancet.com
Background Biological disease-modifying anti-rheumatic drugs (bDMARDs) are
recommended for radiographic axial spondyloarthritis, otherwise known as ankylosing …

Three multicenter, randomized, double‐blind, placebo‐controlled studies evaluating the efficacy and safety of ustekinumab in axial spondyloarthritis

…, C Pacheco, M Brzosko, A Dudek… - Arthritis & …, 2019 - Wiley Online Library
Objective To evaluate the efficacy and safety of ustekinumab in 3 randomized, placebo‐
controlled studies in patients with axial spondyloarthritis (SpA). Studies 1 and 2 included …

ROS-induced autophagy in cancer cells assists in evasion from determinants of immunogenic cell death

AD Garg, AM Dudek, GB Ferreira, T Verfaillie… - Autophagy, 2013 - Taylor & Francis
Calreticulin surface exposure (ecto-CALR), ATP secretion, maturation of dendritic cells
(DCs) and stimulation of T cells are prerequisites for anticancer therapy-induced …