Summary Background The 69th World Health Assembly approved the Global Health Sector
Strategy to eliminate hepatitis C virus (HCV) infection by 2030, which can become a reality …

Summary Background The 69th World Health Assembly approved the Global Health Sector
Strategy to eliminate viral hepatitis by 2030. Although no virological cure exists for hepatitis …

We examine antecedents and outcomes of leader–member exchange (LMX) differentiation,
or the variability in LMX patterns within work groups. Individual-level characteristics and …

Background There are few effective treatment options for patients with recurrent or
metastatic head-and-neck squamous cell carcinoma. Pembrolizumab showed antitumour …

Distinct classes of protective immunity are guided by activation of STAT transcription factor
family members in response to environmental cues. CD4+ regulatory T cells (Tregs) …

Immune homeostasis is dependent on tight control over the size of a population of regulatory
T (Treg) cells capable of suppressing over-exuberant immune responses. The Treg cell …

In the course of infection or autoimmunity, particular transcription factors orchestrate the
differentiation of TH1, TH2 or TH17 effector cells, the responses of which are limited by a …

Background Antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis is a severe
condition encompassing two major syndromes: granulomatosis with polyangiitis (formerly …

Summary Foxp3+ regulatory T (Treg) cells maintain immune homeostasis by limiting
different types of inflammatory responses. Here, we report that miR-146a, one of the miRNAs …

Summary Foxp3+ regulatory T (Treg) cells limit pathogenic immune responses to self-
antigens and foreign antigens. An essential role for microRNA (miRNA) in the maintenance …