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Gout and pseudo-gout-related crystals promote GLUT1-mediated glycolysis that governs NLRP3 and interleukin-1β activation on macrophages.
Renaudin F, Orliaguet L, Castelli F, Fenaille F, Prignon A, Alzaid F, Combes C, Delvaux A, Adimy Y, Cohen-Solal M, Richette P, Bardin T, Riveline JP, Venteclef N, Lioté F, Campillo-Gimenez L, Ea HK. Renaudin F, et al. Among authors: orliaguet l. Ann Rheum Dis. 2020 Nov;79(11):1506-1514. doi: 10.1136/annrheumdis-2020-217342. Epub 2020 Jul 22. Ann Rheum Dis. 2020. PMID: 32699039
Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes.
Julla JB, Girard D, Diedisheim M, Saulnier PJ, Tran Vuong B, Blériot C, Carcarino E, De Keizer J, Orliaguet L, Nemazanyy I, Potier C, Khider K, Tonui DC, Ejlalmanesh T, Ballaire R, Mambu Mambueni H, Germain S, Gaborit B, Vidal-Trécan T, Riveline JP, Garchon HJ, Fenaille F, Lemoine S, Carlier A, Castelli F, Potier L, Masson D, Roussel R, Vandiedonck C, Hadjadj S, Alzaid F, Gautier JF, Venteclef N. Julla JB, et al. Among authors: orliaguet l. Circ Res. 2024 Jan 19;134(2):189-202. doi: 10.1161/CIRCRESAHA.123.322757. Epub 2023 Dec 28. Circ Res. 2024. PMID: 38152893 Free article.
Early macrophage response to obesity encompasses Interferon Regulatory Factor 5 regulated mitochondrial architecture remodelling.
Orliaguet L, Ejlalmanesh T, Humbert A, Ballaire R, Diedisheim M, Julla JB, Chokr D, Cuenco J, Michieletto J, Charbit J, Lindén D, Boucher J, Potier C, Hamimi A, Lemoine S, Blugeon C, Legoix P, Lameiras S, Baudrin LG, Baulande S, Soprani A, Castelli FA, Fenaille F, Riveline JP, Dalmas E, Rieusset J, Gautier JF, Venteclef N, Alzaid F. Orliaguet L, et al. Nat Commun. 2022 Aug 30;13(1):5089. doi: 10.1038/s41467-022-32813-z. Nat Commun. 2022. PMID: 36042203 Free PMC article.
Pyruvate induces torpor in obese mice.
Soto M, Orliaguet L, Reyzer ML, Manier ML, Caprioli RM, Kahn CR. Soto M, et al. Among authors: orliaguet l. Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):810-815. doi: 10.1073/pnas.1717507115. Epub 2018 Jan 8. Proc Natl Acad Sci U S A. 2018. PMID: 29311303 Free PMC article.
Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones.
Girdhar K, Soto M, Huang Q, Orliaguet L, Cederquist C, Sundaresh B, Hu J, Figura M, Raisingani A, Canfora EE, Dirice E, Fujisaka S, Goossens GH, Blaak EE, Kulkarni RN, Kahn CR, Altindis E. Girdhar K, et al. Among authors: orliaguet l. Diabetes. 2022 May 1;71(5):945-960. doi: 10.2337/db21-0382. Diabetes. 2022. PMID: 35212729 Free PMC article.
IRF5 governs liver macrophage activation that promotes hepatic fibrosis in mice and humans.
Alzaid F, Lagadec F, Albuquerque M, Ballaire R, Orliaguet L, Hainault I, Blugeon C, Lemoine S, Lehuen A, Saliba DG, Udalova IA, Paradis V, Foufelle F, Venteclef N. Alzaid F, et al. Among authors: orliaguet l. JCI Insight. 2016 Dec 8;1(20):e88689. doi: 10.1172/jci.insight.88689. JCI Insight. 2016. PMID: 27942586 Free PMC article.