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Crystal-proven gout patients have an increased mortality due to cardiovascular diseases, cancer, and infectious diseases especially when having tophi and/or high serum uric acid levels: a prospective cohort study.
Disveld IJM, Zoakman S, Jansen TLTA, Rongen GA, Kienhorst LBE, Janssens HJEM, Fransen J, Janssen M. Disveld IJM, et al. Among authors: kienhorst lbe. Clin Rheumatol. 2019 May;38(5):1385-1391. doi: 10.1007/s10067-019-04520-6. Epub 2019 Mar 30. Clin Rheumatol. 2019. PMID: 30929152
Patients with gout have short telomeres compared with healthy participants: association of telomere length with flare frequency and cardiovascular disease in gout.
Vazirpanah N, Kienhorst LBE, Van Lochem E, Wichers C, Rossato M, Shiels PG, Dalbeth N, Stamp LK, Merriman TR, Janssen M, Radstake TRDJ, Broen JC. Vazirpanah N, et al. Among authors: kienhorst lbe. Ann Rheum Dis. 2017 Jul;76(7):1313-1319. doi: 10.1136/annrheumdis-2016-210538. Epub 2017 Mar 27. Ann Rheum Dis. 2017. PMID: 28347991 Free article.
Gout Is a Chronic Inflammatory Disease in Which High Levels of Interleukin-8 (CXCL8), Myeloid-Related Protein 8/Myeloid-Related Protein 14 Complex, and an Altered Proteome Are Associated With Diabetes Mellitus and Cardiovascular Disease.
Kienhorst LB, van Lochem E, Kievit W, Dalbeth N, Merriman ME, Phipps-Green A, Loof A, van Heerde W, Vermeulen S, Stamp LK, van Koolwijk E, de Graaf J, Holzinger D, Roth J, Janssens HJ, Merriman TR, Broen JC, Janssen M, Radstake TR. Kienhorst LB, et al. Arthritis Rheumatol. 2015 Dec;67(12):3303-13. doi: 10.1002/art.39318. Arthritis Rheumatol. 2015. PMID: 26248007