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The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype.
Int J Parasitol. 2013 Mar;43(3-4):211-23. doi: 10.1016/j.ijpara.2012.12.001. Epub 2013 Jan 3.
Int J Parasitol. 2013.
PMID: 23291461
Free PMC article.
The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis.
Harnett MM, Kean DE, Boitelle A, McGuiness S, Thalhamer T, Steiger CN, Egan C, Al-Riyami L, Alcocer MJ, Houston KM, Gracie JA, McInnes IB, Harnett W.
Harnett MM, et al. Among authors: kean de.
Ann Rheum Dis. 2008 Apr;67(4):518-23. doi: 10.1136/ard.2007.073502. Epub 2007 Aug 17.
Ann Rheum Dis. 2008.
PMID: 17704067
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Dissecting Ascaris glycosphingolipids for immunomodulatory moieties--the use of synthetic structural glycosphingolipid analogues.
Kean DE, Ohtsuka I, Sato K, Hada N, Takeda T, Lochnit G, Geyer R, Harnett MM, Harnett W.
Kean DE, et al.
Parasite Immunol. 2006 Mar;28(3):69-76. doi: 10.1111/j.1365-3024.2005.00801.x.
Parasite Immunol. 2006.
PMID: 16441504
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Differential polarization of immune responses by plant 2S seed albumins, Ber e 1, and SFA8.
Kean DE, Goodridge HS, McGuinness S, Harnett MM, Alcocer MJ, Harnett W.
Kean DE, et al.
J Immunol. 2006 Aug 1;177(3):1561-6. doi: 10.4049/jimmunol.177.3.1561.
J Immunol. 2006.
PMID: 16849463
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