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chavez alvarez a[au]
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Chavez-Alvarez LA[au]
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Branched alkyl of phenyl 4-(2-oxo-3-alkylimidazolidin-1-yl)benzenesulfonates as unique cytochrome P450 1A1-activated antimitotic prodrugs: Biological evaluation and mechanism of bioactivation.
Eur J Med Chem. 2022 Feb 5;229:114003. doi: 10.1016/j.ejmech.2021.114003. Epub 2021 Nov 19.
Eur J Med Chem. 2022.
PMID: 34839998
Preparation and biological evaluation of new antimicrotubule agents: Modification of the imidazolidin-2-one moiety of phenyl 4-(2-oxoimidazolidin-1-yl)benzenesulfonates.
Gagné-Boulet M, Bouzriba C, Chavez Alvarez AC, Fortin S.
Gagné-Boulet M, et al. Among authors: chavez alvarez ac.
Chem Biol Drug Des. 2022 Feb;99(2):187-196. doi: 10.1111/cbdd.13971. Epub 2021 Oct 17.
Chem Biol Drug Des. 2022.
PMID: 34623027
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Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes.
Chavez Alvarez AC, Bouzriba C, Moreau E, Auzeloux P, Besse S, Ouellette V, Zarifi Khosroshahi M, Côté MF, Pilote S, Miot-Noirault E, Chezal JM, Simard C, C-Gaudreault R, Fortin S.
Chavez Alvarez AC, et al.
J Med Chem. 2023 Feb 23;66(4):2477-2497. doi: 10.1021/acs.jmedchem.2c01268. Epub 2023 Feb 13.
J Med Chem. 2023.
PMID: 36780426
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4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamides as new antimitotic prodrugs activated by cytochrome P450 1A1 in breast cancer cells.
Chavez Alvarez AC, Zarifi Khosroshahi M, Côté MF, Gagné-Boulet M, Fortin S.
Chavez Alvarez AC, et al.
Bioorg Med Chem. 2018 Oct 1;26(18):5045-5052. doi: 10.1016/j.bmc.2018.09.001. Epub 2018 Sep 4.
Bioorg Med Chem. 2018.
PMID: 30201525
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4-(3-Alkyl-2-oxoimidazolidin-1-yl)-N-phenylbenzenesulfonamide salts: Novel hydrosoluble prodrugs of antimitotics selectively bioactivated by the cytochrome P450 1A1 in breast cancer cells.
Ouellette V, Chavez Alvarez AC, Bouzriba C, Hamel-Côté G, Fortin S.
Ouellette V, et al. Among authors: chavez alvarez ac.
Bioorg Chem. 2023 Nov;140:106820. doi: 10.1016/j.bioorg.2023.106820. Epub 2023 Sep 1.
Bioorg Chem. 2023.
PMID: 37672952
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Phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonates and phenyl 4-(2-oxopyrrolidin-1-yl)benzenesulfonamides as new antimicrotubule agents targeting the colchicine-binding site.
Gagné-Boulet M, Bouzriba C, Chavez Alvarez AC, Fortin S.
Gagné-Boulet M, et al. Among authors: chavez alvarez ac.
Eur J Med Chem. 2021 Mar 5;213:113136. doi: 10.1016/j.ejmech.2020.113136. Epub 2021 Jan 6.
Eur J Med Chem. 2021.
PMID: 33472119
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