First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)-Pan-American League of Associations of Rheumatology (PANLAR)

Ann Rheum Dis. 2018 Nov;77(11):1549-1557. doi: 10.1136/annrheumdis-2018-213512. Epub 2018 Jul 25.

Abstract

Systemic lupus erythematosus (SLE), a complex and heterogeneous autoimmune disease, represents a significant challenge for both diagnosis and treatment. Patients with SLE in Latin America face special problems that should be considered when therapeutic guidelines are developed. The objective of the study is to develop clinical practice guidelines for Latin American patients with lupus. Two independent teams (rheumatologists with experience in lupus management and methodologists) had an initial meeting in Panama City, Panama, in April 2016. They selected a list of questions for the clinical problems most commonly seen in Latin American patients with SLE. These were addressed with the best available evidence and summarised in a standardised format following the Grading of Recommendations Assessment, Development and Evaluation approach. All preliminary findings were discussed in a second face-to-face meeting in Washington, DC, in November 2016. As a result, nine organ/system sections are presented with the main findings; an 'overarching' treatment approach was added. Special emphasis was made on regional implementation issues. Best pharmacologic options were examined for musculoskeletal, mucocutaneous, kidney, cardiac, pulmonary, neuropsychiatric, haematological manifestations and the antiphospholipid syndrome. The roles of main therapeutic options (ie, glucocorticoids, antimalarials, immunosuppressant agents, therapeutic plasma exchange, belimumab, rituximab, abatacept, low-dose aspirin and anticoagulants) were summarised in each section. In all cases, benefits and harms, certainty of the evidence, values and preferences, feasibility, acceptability and equity issues were considered to produce a recommendation with special focus on ethnic and socioeconomic aspects. Guidelines for Latin American patients with lupus have been developed and could be used in similar settings.

Keywords: lupus nephritis; systemic lupus erythematosus; treatment.

Publication types

  • Practice Guideline
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiphospholipid Syndrome / drug therapy*
  • Antiphospholipid Syndrome / etiology
  • Heart Diseases / drug therapy
  • Heart Diseases / etiology
  • Hematologic Diseases / drug therapy*
  • Hematologic Diseases / etiology
  • Humans
  • Kidney Diseases / drug therapy*
  • Kidney Diseases / etiology
  • Latin America
  • Lung Diseases / drug therapy
  • Lung Diseases / etiology
  • Lupus Erythematosus, Systemic / complications
  • Lupus Erythematosus, Systemic / drug therapy*
  • Lupus Nephritis / drug therapy
  • Lupus Nephritis / etiology
  • Mental Disorders / drug therapy
  • Mental Disorders / etiology
  • Musculoskeletal Diseases / drug therapy
  • Musculoskeletal Diseases / etiology
  • Skin Diseases / drug therapy
  • Skin Diseases / etiology
  • Standard of Care