Abstract
Notch signaling has been implicated in a wide variety of processes from cell-fate decisions, tissue patterning and morphogenesis to human diseases and cancer. A model for Notch directly regulating gene expression has been proposed and at least two signaling pathways have been identified; however, the molecular mechanism(s) by which Notch signaling produces so many outcomes remains unclear.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Avian Proteins*
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Endopeptidases / metabolism
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Forkhead Transcription Factors
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Humans
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Ligands
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Membrane Proteins / metabolism*
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Oncogene Proteins*
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Proto-Oncogene Proteins
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Receptors, Notch
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Signal Transduction*
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Viral Proteins*
Substances
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Avian Proteins
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Forkhead Transcription Factors
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Ligands
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Membrane Proteins
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Oncogene Proteins
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Proto-Oncogene Proteins
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Receptors, Notch
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Viral Proteins
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v-qin protein, Avian sarcoma virus 31
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Endopeptidases