The allopurinol hypersensitivity syndrome

Neth J Med. 1998 Mar;52(3):107-10. doi: 10.1016/s0300-2977(97)00088-0.

Abstract

We describe a 61-year-old male patient who was treated with allopurinol and developed fever, a skin rash, eosinophilia and severe renal and liver dysfunction. We discuss the allopurinol hypersensitivity syndrome as a serious complication of the use of allopurinol, and briefly review the aetiology, prevention and treatment modalities.

Publication types

  • Case Reports

MeSH terms

  • Acute Kidney Injury / diagnosis
  • Acute Kidney Injury / drug therapy
  • Acute Kidney Injury / etiology
  • Allopurinol / adverse effects*
  • Anti-Inflammatory Agents / therapeutic use
  • Diagnosis, Differential
  • Drug Hypersensitivity / diagnosis
  • Drug Hypersensitivity / etiology*
  • Gout / drug therapy
  • Gout Suppressants / adverse effects*
  • Humans
  • Male
  • Middle Aged
  • Prednisone / therapeutic use
  • Syndrome

Substances

  • Anti-Inflammatory Agents
  • Gout Suppressants
  • Allopurinol
  • Prednisone