Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis

C Vandevyver; P Raus; P Stinissen; L Philippaerts; J J Cassiman; J Raus

doi:10.1111/j.1744-313x.1994.tb00208.x

Polymorphism of the tumour necrosis factor beta gene in multiple sclerosis and rheumatoid arthritis

Eur J Immunogenet. 1994 Oct;21(5):377-82. doi: 10.1111/j.1744-313x.1994.tb00208.x.

Authors

C Vandevyver¹, P Raus, P Stinissen, L Philippaerts, J J Cassiman, J Raus

Affiliation

¹ Department of Immunology/Biotechnology, Dr L. Willems-Institut, Diepenbeek, Belgium.

PMID: 9098447
DOI: 10.1111/j.1744-313x.1994.tb00208.x

Abstract

We evaluated the TNF-beta gene polymorphism in two HLA-associated autoimmune diseases, multiple sclerosis (MS) and rheumatoid arthritis (RA). The TNF-beta allele and genotype frequencies were not significantly different in the patient populations, compared to controls. An increased frequency of the TNF-beta*2 allele was observed in HLA-DR2+ vs. HLA-DR2- MS patients. No such association was seen in HLA-DR4+ RA patients.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Alleles
Arthritis, Rheumatoid / epidemiology
Arthritis, Rheumatoid / genetics*
Autoimmune Diseases / epidemiology
Autoimmune Diseases / genetics*
Disease Susceptibility
Genotype
HLA-DR2 Antigen / genetics
HLA-DR4 Antigen / genetics
Humans
Lymphotoxin-alpha / genetics*
Multiple Sclerosis / epidemiology
Multiple Sclerosis / genetics*
Polymorphism, Genetic
Risk

Substances

HLA-DR2 Antigen
HLA-DR4 Antigen
Lymphotoxin-alpha