Mechanism of action of leflunomide: in vivo uridine administration reverses its inhibition of lymphocyte proliferation

Transplant Proc. 1996 Dec;28(6):3082-4.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Dihydroorotate Dehydrogenase
  • Immunosuppressive Agents / pharmacology*
  • Isoxazoles / pharmacology*
  • Leflunomide
  • Lymphocyte Activation / drug effects*
  • Male
  • Oxidoreductases / antagonists & inhibitors*
  • Oxidoreductases Acting on CH-CH Group Donors*
  • Rats
  • Rats, Inbred Lew
  • Thymidine / metabolism
  • Uridine / pharmacology*

Substances

  • Dihydroorotate Dehydrogenase
  • Immunosuppressive Agents
  • Isoxazoles
  • Oxidoreductases
  • Oxidoreductases Acting on CH-CH Group Donors
  • Leflunomide
  • Thymidine
  • Uridine