A novel mechanism of action of the immunomodulatory drug, leflunomide: augmentation of the immunosuppressive cytokine, TGF-beta 1, and suppression of the immunostimulatory cytokine, IL-2

Transplant Proc. 1996 Dec;28(6):3079-80.

Authors

W W Cao¹, P N Kao, Y Aoki, J C Xu, R A Shorthouse, R E Morris

Affiliation

¹ Probe ID/Department, Chiron Corp, Emeryville, California, USA.

PMID: 8962191

No abstract available

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cells, Cultured
Gene Expression
Humans
Immunosuppressive Agents / pharmacology*
Interleukin-2 / antagonists & inhibitors
Interleukin-2 / biosynthesis*
Isoxazoles / pharmacology*
Jurkat Cells
Leflunomide
Transcription, Genetic
Transforming Growth Factor beta / biosynthesis*

Substances

Immunosuppressive Agents
Interleukin-2
Isoxazoles
Transforming Growth Factor beta
Leflunomide