Abstract
Thrombospondin-1 (TSP-1), a trimeric high molecular weight glycoprotein, is one of the major secreted proteins of human platelets and an extracellular matrix component of a variety of cells including vascular endothelial cells and tumor cells. TSP-1 has been shown to be highly expressed in human malignant tissues and present in higher than normal levels in the plasma of cancer patients. TSP-1 has also been shown to promote hematogenous tumor spread, tumor cell adhesion and invasion, and angiogenesis. Overall these studies provide compelling evidence for the conclusion that TSP-1 plays an important role in tumor progression.
Publication types
-
Research Support, U.S. Gov't, P.H.S.
-
Review
MeSH terms
-
Blood Platelets / metabolism
-
Blood Proteins / metabolism
-
CD36 Antigens / genetics
-
Cell Adhesion Molecules / biosynthesis*
-
Cell Adhesion Molecules / genetics
-
Cell Adhesion Molecules / pharmacology
-
Extracellular Matrix Proteins / metabolism
-
Humans
-
Membrane Glycoproteins / biosynthesis*
-
Membrane Glycoproteins / genetics
-
Membrane Glycoproteins / pharmacology
-
Neoplasms / metabolism*
-
Neoplasms / pathology
-
Neovascularization, Pathologic / physiopathology
-
Neovascularization, Physiologic / drug effects
-
Thrombospondins
-
Tumor Cells, Cultured
Substances
-
Blood Proteins
-
CD36 Antigens
-
Cell Adhesion Molecules
-
Extracellular Matrix Proteins
-
Membrane Glycoproteins
-
Thrombospondins