Abstract
Based on the elevated expression of oncogenes in proliferating transformed-appearing synoviocytes we searched for the possible involvement of a viral agent in the pathogenesis of RA. We report the detection of virus-like particles with retroviral C type morphology in SF, which lack the typical morphologic as well as immunohistochemical features of the human T-lymphotropic and immunodeficiency viruses.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Arthritis, Rheumatoid / microbiology*
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Arthritis, Rheumatoid / pathology
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Cell Line
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Cells, Cultured
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Fibroblasts / microbiology
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Humans
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Microscopy, Electron
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Microscopy, Immunoelectron
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Synovial Fluid / microbiology*
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Synovial Membrane / microbiology
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Synovial Membrane / pathology
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Virion / isolation & purification*