Abstract
Rheumatoid arthritis (RA) serum inhibits complement-mediated inhibition of immune precipitation (solubilization). We have isolated inhibitory activity from RA sera and shown that it is a property of IgM-rheumatoid factor (IgM-RF) and, to a lesser extent, IgG-RF.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antigen-Antibody Complex / metabolism*
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Arthritis, Rheumatoid / immunology*
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Chemical Precipitation
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Complement System Proteins / immunology*
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Electrophoresis, Polyacrylamide Gel
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Humans
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Immunoglobulin M / immunology*
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Rheumatoid Factor / immunology*
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Solubility
Substances
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Antigen-Antibody Complex
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Immunoglobulin M
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Complement System Proteins
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Rheumatoid Factor