Abstract
Normal and rheumatoid synovial cells have been analyzed in frozen sections and in suspension. HLA-DR-expressing, macrophage-like cells are demonstrated in normal synovial intima and in rheumatoid tissue. Suspended normal synoviocytes equaled peripheral blood non-T lymphocytes as stimulators of mixed lymphocyte reactions, whereas adherent rheumatoid synovial cells were extremely efficient as such stimulators and in presenting soluble antigens to autologous T lymphocytes. This HLA-DR-dependent T lymphocyte regulation might provide a cellular basis for the HLA-D haplotype-arthritis associations.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Antibodies, Monoclonal / immunology
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Arthritis, Rheumatoid / immunology
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Arthritis, Rheumatoid / pathology
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Esterases / biosynthesis
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HLA-DR Antigens
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Histocompatibility Antigens Class II / immunology*
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Humans
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Lymphocyte Culture Test, Mixed
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Macrophages / immunology*
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Phenotype
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Receptors, Fc / immunology
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Synovial Membrane / cytology
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Synovial Membrane / enzymology
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Synovial Membrane / immunology*
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Synovial Membrane / pathology
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T-Lymphocytes / immunology*
Substances
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Antibodies, Monoclonal
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HLA-DR Antigens
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Histocompatibility Antigens Class II
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Receptors, Fc
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Esterases