Abstract
Neuropsychiatric abnormalities in patients with systemic lupus have been recognized for more than a century. Although the prognosis of lupus has improved, involvement of the nervous system continues to be a major feature, with some abnormality recognized in 50 to 66 per cent of lupus patients. Diagnosis and therapy of neurologic disease remain the most difficult clinical challenges in the management of SLE.
MeSH terms
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Anticoagulants / therapeutic use
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Autoantibodies / physiology
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Biomechanical Phenomena
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Blood Coagulation
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Central Nervous System Diseases / diagnosis
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Central Nervous System Diseases / etiology*
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Central Nervous System Diseases / physiopathology
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Electroencephalography
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Humans
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Immunosuppressive Agents / therapeutic use
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Lupus Erythematosus, Systemic / complications*
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Magnetic Resonance Imaging
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Mental Disorders / diagnosis
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Mental Disorders / etiology*
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Mental Disorders / physiopathology
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Tomography, X-Ray Computed
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Vasculitis / complications
Substances
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Anticoagulants
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Autoantibodies
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Immunosuppressive Agents