Abstract
We describe a cell in which association of a major histocompatibility complex class I heavy chain with beta 2-microglobulin is induced by a peptide derived from influenza nucleoprotein. Association of antigenic peptides with the binding site of class I molecules may be required for correct folding of the heavy chain, association with beta 2-microglobulin and transport of the antigen-MHC complex to the cell surface.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Cell Line
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Cell Membrane / immunology
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Cell Transformation, Viral
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Histocompatibility Antigens Class I / genetics*
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Histocompatibility Antigens Class I / immunology
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Histocompatibility Antigens Class I / isolation & purification
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Macromolecular Substances
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Mutation
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Nucleocapsid Proteins
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Nucleoproteins / immunology
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Orthomyxoviridae / genetics
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Protein Conformation
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RNA-Binding Proteins*
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Viral Core Proteins*
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Viral Proteins / immunology
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beta 2-Microglobulin / immunology
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beta 2-Microglobulin / isolation & purification
Substances
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Histocompatibility Antigens Class I
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Macromolecular Substances
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NP protein, Influenza A virus
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Nucleocapsid Proteins
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Nucleoproteins
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RNA-Binding Proteins
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Viral Core Proteins
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Viral Proteins
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beta 2-Microglobulin