Gut-Busters: IL-17 Ain't Afraid of No IL-23

Immunity. 2015 Oct 20;43(4):620-2. doi: 10.1016/j.immuni.2015.10.001.

Abstract

Interleukin-23 (IL-23) is considered a critical regulator of IL-17 in lymphocytes. Whereas antibodies targeting IL-23 ameliorate colitis, IL-17 neutralization exacerbates disease. In this issue, Cua and colleagues and Maxwell and colleagues show that IL-17 maintains intestinal barrier integrity, helping explain this dichotomy (Lee et al., 2015; Maxwell et al., 2015).

Publication types

  • Comment

MeSH terms

  • Animals
  • Colitis / immunology*
  • Colitis / physiopathology*
  • Female
  • Humans
  • Interleukin-17 / physiology*
  • Interleukin-23 / physiology*
  • Intestinal Mucosa / physiopathology*
  • Receptors, Interleukin-17 / physiology*

Substances

  • Interleukin-17
  • Interleukin-23
  • Receptors, Interleukin-17