Modulation of CD4+ and CD8+ T-Cell Function by Interleukin 19 and Interleukin 24 During Filarial Infections

J Infect Dis. 2016 Mar 1;213(5):811-5. doi: 10.1093/infdis/jiv497. Epub 2015 Oct 20.

Abstract

Interleukin 19 (IL-19) and interleukin 24 (IL-24) are cytokines that are highly expressed in filarial infections. To study the role of IL-19 and IL-24 in regulating T-cell responses, we examined the frequency of T-helper type 1 (Th1)/Tc1, Th2/Tc2, Th9/Tc9, Th17/Tc17, Th22/Tc22, and Tr1 cells in 26 filariae-infected individuals stimulated with filarial antigen following IL-19 or IL-24 neutralization. IL-19 or IL-24 neutralization resulted in significantly enhanced frequencies of Th1/Tc1 and/or Th17/Tc17 cells and significantly reduced frequencies of Th2/Tc2, Tr1, and/or Th9/Tc9 cells. Thus, we demonstrate that IL-19 and IL-24 are associated with the modulation of T-cell responses in filarial infections.

Keywords: IL-10; IL-19; IL-24; T cells; cytokines; filarial infections.

Publication types

  • Research Support, N.I.H., Intramural

MeSH terms

  • CD4-Positive T-Lymphocytes / physiology*
  • CD8-Positive T-Lymphocytes / physiology*
  • Filariasis / immunology
  • Filariasis / metabolism*
  • Humans
  • Interleukin-10 / genetics
  • Interleukin-10 / metabolism
  • Interleukins / genetics
  • Interleukins / metabolism*
  • T-Lymphocyte Subsets

Substances

  • IL10 protein, human
  • IL19 protein, human
  • Interleukins
  • interleukin-24
  • Interleukin-10