Balance and imbalance in the immune system: life on the edge

Suzanne L Topalian; Arlene H Sharpe

doi:10.1016/j.immuni.2014.11.005

Balance and imbalance in the immune system: life on the edge

Immunity. 2014 Nov 20;41(5):682-4. doi: 10.1016/j.immuni.2014.11.005. Epub 2014 Nov 20.

Authors

Suzanne L Topalian¹, Arlene H Sharpe²

Affiliations

¹ Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA. Electronic address: stopali1@jhmi.edu.
² Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA 02115, USA. Electronic address: arlene_sharpe@hms.harvard.edu.

Abstract

CTLA-4 is a key immune checkpoint in maintaining self-tolerance, which can be co-opted by cancer to evade immune attack. In Science, Kuehn et al. (2014) describe clinical manifestations from inherited heterozygous CTLA4 mutations, and some are reminiscent of immune-related consequences from anti-CTLA-4 cancer therapy.

Publication types

Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Comment

MeSH terms

Animals
CTLA-4 Antigen / genetics*
Female
Germ-Line Mutation*
Haploinsufficiency*
Humans
Immune System Diseases / genetics*
Immunity / genetics*
Male

Substances

CTLA-4 Antigen

Abstract

Publication types

MeSH terms

Substances

Grants and funding