Abstract
Two siblings with chronic hemolytic anemia due to red cell pyrimidine-5'-nucleotidase (P-5'-N) deficiency, presented within a few days of each other with a febrile illness and pancytopenia. The cause of the aplastic crisis was an acute infection with human B19 parvovirus (B19 HPV) as proven by immunoelectron microscopy and DNA hybridization. This is the first report on the association of B19-HPV-related aplastic crisis with P-5'-N deficiency.
Publication types
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Case Reports
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Research Support, Non-U.S. Gov't
MeSH terms
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5'-Nucleotidase
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Adolescent
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Adult
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Anemia, Hemolytic, Congenital / enzymology
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Anemia, Hemolytic, Congenital / etiology*
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Anemia, Hemolytic, Congenital / microbiology
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DNA, Viral / blood
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Electrophoresis, Agar Gel
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Erythrocytes / enzymology*
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Erythrocytes / microbiology
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Female
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Humans
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Male
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Nucleotidases / blood
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Nucleotidases / deficiency*
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Parvoviridae Infections / complications*
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Parvoviridae Infections / enzymology
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Parvoviridae Infections / microbiology
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Virion / ultrastructure
Substances
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DNA, Viral
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Nucleotidases
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5'-Nucleotidase