Association of class I, II, and III MHC gene products with systemic lupus erythematosus. Results of a Central European multicenter study

Rheumatol Int. 1989;9(1):13-8. doi: 10.1007/BF00270284.

Abstract

Class I, II, and III MHC gene products were examined in 248 Central European SLE patients. The previously reported association with HLA-A1, -B8 and -DR3, and C4AQ0 alleles was confirmed. The frequency of HLA-DR2 was also slightly elevated in SLE patients, while no increase in C4BQ0 alleles was observed. Additional findings were a significantly increased frequency of HLA-B13 and a significant decrease of HLA-B44.

Publication types

  • Clinical Trial
  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alleles
  • Europe
  • Gene Frequency
  • Genes, MHC Class I*
  • Genes, MHC Class II*
  • HLA Antigens / analysis*
  • HLA Antigens / genetics
  • Humans
  • Lupus Erythematosus, Systemic / genetics
  • Lupus Erythematosus, Systemic / immunology*
  • Major Histocompatibility Complex*
  • Multicenter Studies as Topic

Substances

  • HLA Antigens