Abstract
B cells and primary carcinomas express a surface molecule, Bp50 (CDw40), absent from other hematopoietic cells and from normal epithelium, and thought to play a regulatory role in B-cell maturation and epithelial neoplasia. In this work the sequence of a cDNA clone encoding Bp50 was analyzed by a newly derived transition matrix method. Among several interesting relationships with known receptors was found an extensive homology with the nerve growth factor receptor. The mRNA is induced by gamma-interferon in both B cells and epithelial neoplasms, suggesting a role for the molecule in the development of carcinomas at sites of chronic inflammation.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amino Acid Sequence
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Antigens, Differentiation, B-Lymphocyte / genetics*
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B-Lymphocytes / immunology*
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Base Sequence
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Biological Factors / pharmacology
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CD40 Antigens
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Carcinoma / genetics
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Carcinoma / immunology
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Carcinoma / metabolism
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Cytokines
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Gene Expression Regulation
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HLA-DR Antigens / genetics
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Humans
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Lymphocyte Activation
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Molecular Sequence Data
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Mutation
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Nerve Growth Factors / metabolism*
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Receptors, Cell Surface / genetics*
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Receptors, Nerve Growth Factor
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Sequence Homology, Nucleic Acid
Substances
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Antigens, Differentiation, B-Lymphocyte
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Biological Factors
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CD40 Antigens
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Cytokines
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HLA-DR Antigens
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Nerve Growth Factors
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Receptors, Cell Surface
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Receptors, Nerve Growth Factor