Abstract
The frequencies of C4A and C4B alleles were determined in 66 adults with myositis in relation to HLA class I and II. In whites with myositis, the C4A*Q0 allele occurred in 13/31 (47%) as compared to 25/101 (25%) normal controls (p = 0.08, relative risk = 2.7). Only 11/35 (31%) of black patients with myositis had a C4A*Q0 allele compared to 11/55 (20%) of controls (p = NS, RR = 1.8). Thus, the MHC class III genes do not appear to be the primary genetic risk factors for myositis in adults.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Alleles*
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Black People / genetics*
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Chromosome Deletion
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Complement C4 / genetics*
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Dermatomyositis / ethnology
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Dermatomyositis / genetics
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Dermatomyositis / immunology
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Genes*
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HLA Antigens / analysis
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HLA Antigens / genetics
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Humans
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Myositis / ethnology
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Myositis / genetics*
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Myositis / immunology
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Phenotype
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United States
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White People / genetics*
Substances
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Complement C4
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HLA Antigens