Bone cells crosstalk: noncanonical Roring in the Wnt

Roland Baron; Hiroaki Saito; Francesca Gori

doi:10.1016/j.cmet.2012.03.014

Bone cells crosstalk: noncanonical Roring in the Wnt

Cell Metab. 2012 Apr 4;15(4):415-7. doi: 10.1016/j.cmet.2012.03.014.

Authors

Roland Baron¹, Hiroaki Saito, Francesca Gori

Affiliation

¹ Harvard Medical School, 25 Shattuck Street, Boston, MA 02115, USA. roland_baron@hsdm.harvard.edu

PMID: 22482722
DOI: 10.1016/j.cmet.2012.03.014

Abstract

It is well established that canonical Wnt signaling in bone regulates bone mass. Much less is known about the role of noncanonical Wnt signaling. Maeda and colleagues now report in Nature Medicine that Wnt5a-Ror2 crosstalk between bone cells enhances bone resorption, thereby negatively regulating skeletal homeostasis (Maeda et al., 2012).

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