Abstract
We have recently reported a new family of nuclear autoantibodies in a subset of patients with primary biliary cirrhosis. These antibodies bind to a nuclear envelope polypeptide(s) of approximately 200 kD, the exact identity of which was not established. In this study, we show that all of these autoantibodies are directed against a 210-kD integral membrane glycoprotein of the nuclear pore.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Autoantigens / immunology*
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Blotting, Western
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Fluorescent Antibody Technique
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Humans
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Liver Cirrhosis, Biliary / immunology*
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Membrane Glycoproteins / immunology*
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Molecular Weight
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Nuclear Envelope / immunology*
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Nuclear Proteins / immunology*
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Precipitin Tests
Substances
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Autoantigens
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Membrane Glycoproteins
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Nuclear Proteins