Dysregulated neutrophil--endothelial interaction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides: implications for pathogenesis and disease intervention

Nan Hu; Johanna Westra; Cees G M Kallenberg

doi:10.1016/j.autrev.2011.04.004

Dysregulated neutrophil--endothelial interaction in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitides: implications for pathogenesis and disease intervention

Autoimmun Rev. 2011 Jul;10(9):536-43. doi: 10.1016/j.autrev.2011.04.004. Epub 2011 Apr 13.

Authors

Nan Hu¹, Johanna Westra, Cees G M Kallenberg

Affiliation

¹ Department of Rheumatology and Clinical Immunology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.

PMID: 21513817
DOI: 10.1016/j.autrev.2011.04.004

Abstract

The interplay between neutrophils and endothelial cells allows ANCA to become pathogenic and results in uncontrolled inflammation in the vessel wall. This review presents an overall view on neutrophil-endothelial interaction during inflammation with a focus on ANCA-associated vasculitis, and summarizes the effector mechanisms which cause vascular damage in AAV. In addition, potential elements for disease intervention based on this process are discussed.

Publication types

Review

MeSH terms

Animals
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / immunology*
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / physiopathology*
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis / therapy
Cell Adhesion Molecules / immunology
Cell Communication / immunology
Endothelial Cells / immunology*
Humans
Immunomodulation
Inflammation
Neutrophils / immunology*
Vascular Diseases / immunology
Vascular Diseases / physiopathology

Substances

Cell Adhesion Molecules