Rheumatoid arthritis susceptibility loci at chromosomes 10p15, 12q13 and 22q13

Nat Genet. 2008 Oct;40(10):1156-9. doi: 10.1038/ng.218. Epub 2008 Sep 14.

Abstract

The WTCCC study identified 49 SNPs putatively associated with rheumatoid arthritis at P = 1 x 10(-4) - 1 x 10(-5) (tier 3). Here we show that three of these SNPs, mapping to chromosome 10p15 (rs4750316), 12q13 (rs1678542) and 22q13 (rs3218253), are also associated (trend P = 4 x 10(-5), P = 4 x 10(-4) and P = 4 x 10(-4), respectively) in a validation study of 4,106 individuals with rheumatoid arthritis and an expanded reference group of 11,238 subjects, confirming them as true susceptibility loci in individuals of European ancestry.

Publication types

  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arthritis, Rheumatoid / genetics*
  • Arthritis, Rheumatoid / pathology
  • Case-Control Studies
  • Chromosome Mapping
  • Chromosomes, Human, Pair 10 / genetics*
  • Chromosomes, Human, Pair 12 / genetics*
  • Chromosomes, Human, Pair 22 / genetics*
  • Genetic Linkage
  • Genetic Predisposition to Disease / genetics*
  • Humans
  • Polymorphism, Single Nucleotide / genetics