The aim of the study was to investigate the effect of osteoarthritis (OA) on hand function in elderly patients. One hundred elderly patients with a mean age of 68.50 +/- 6.37 years (87 women, 13 men) were enrolled to the study. Radiological hand OA was defined as the presence of Kellgren-Lawrence (K-L) grade > or = 2. Grip strength, and lateral, tip, and three-fingered pinches were measured. Hand function was assessed by Dreiser's functional index. Subjective hand disability was assessed by the hand disability index of Stanford Health Assessment Questionnaire (HAQ) and by self-reported functional limitation. Coordination was evaluated by testing for rapid alternating movement (RAM) and fine finger movement (FFM). The Jebsen test of hand function was used to determine functional hand use. Forty patients had K-L > or = 2 radiological hand OA, and 60 patients had K-L = 0 and 1 and were accepted as the control group. In the clinical examination, 54 patients had Heberden's nodules and 35 had Bouchard's nodules. Self-reported functional limitation tests (activities like carrying a bundle and handling or fingering small objects) were significantly worse in patients with radiographic hand OA, and also, non-dominant hand RAM was slower in the same group. According to the evaluation of the radiologic grades of OA, grades 3-4 OA had higher scores than the control and grade 2 OA group. Our results suggest that there is a lack of association between radiological hand OA and Jebsen test and objective hand functions like grip and pinch strength, but the patients with radiological hand OA have restrictions in the self-reported functional limitation test. The presence of tenderness, pain, and Heberden's and Bouchard's nodules had a negative effect on hand functions. Dreiser's functional index and the hand disability index of HAQ were found as related parameters with the radiological grade of OA.