Abstract
The role of resveratrol and curcumin is well documented in cancer, inflammation, diabetes and various other diseases. However, their immunosuppressive action on T cells, B cells and macrophages is not well documented. In the present study, we have ascertained the effect of resveratrol and curcumin on T and B cells and macrophages. The most striking findings were that both resveratrol and curcumin suppressed the activity of T and B cells and macrophages, as evidenced by significant inhibition in proliferation, antibody production and lymphokine secretion. Interestingly, curcumin imparted immunosuppression by mainly down-regulating the expression of CD28 and CD80 and up-regulating CTLA-4. Resveratrol also functioned by decreasing the expression of CD28 and CD80, as well as by augmenting the production of interleukin (IL)-10.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, CD / immunology*
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Antigens, Differentiation / immunology*
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Antineoplastic Agents / pharmacology*
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B-Lymphocytes / drug effects
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B7-1 Antigen / immunology
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CD28 Antigens / immunology
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CD4-Positive T-Lymphocytes / immunology
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CD40 Antigens / immunology
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CTLA-4 Antigen
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Cell Proliferation / drug effects
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Cell Survival
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Cells, Cultured
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Concanavalin A
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Curcumin / pharmacology*
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Flow Cytometry
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Immunoglobulin G / immunology
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Lipopolysaccharides
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Lymphocytes / immunology*
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Macrophage Activation / drug effects
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Macrophages / drug effects
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Mice
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Mice, Inbred BALB C
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Resveratrol
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Stilbenes / pharmacology*
Substances
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Antigens, CD
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Antigens, Differentiation
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Antineoplastic Agents
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B7-1 Antigen
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CD28 Antigens
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CD40 Antigens
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CTLA-4 Antigen
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Ctla4 protein, mouse
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Immunoglobulin G
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Lipopolysaccharides
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Stilbenes
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Concanavalin A
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Curcumin
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Resveratrol